IMO, in Linux YUV 420 is fine for most purposes. Video up to 1080p full frame runs great at up to 30 fps and everything else looks and behaves just like a standard desktop with a Pi 4B and even the 3B and 3B+ were already pretty good.
We were going to do somewhere between 200 - 300 RPis with XenDesktop but then without warning, the project got canned and the powers that be decided on thick clients (PCs). I will probably never know why that decision was made. I spent the last 4 to 5 years working on helping to make the Pi a viable thin client for Citrix, then this happened. It hit hard and I'm still not over it.