I’m working with a client running Citrix Virtual Apps and Desktops 2507 on‑prem with Citrix Workspace app 2507 LTSR (some endpoints on 2511) and the latest Microsoft Teams with VDI optimization enabled.I’m trying to confirm best practices around Client USB device redirection for audio devices. I don’t see this setting listed as a requirement in the Citrix 2507 Teams optimization documentation, and my understanding is that USB headsets used with Teams/Zoom are handled through HDX/virtual audio channels rather than generic USB redirection. The client currently has Client USB device redirection enabled, assuming it’s required for Teams and Zoom, but this is also allowing USB storage devices into the Citrix session. I would prefer to disable it (or lock it down) if it’s not actually needed for headset audio. For those running a similar setup, is there any reason to enable Client USB device redirection specifically for Teams/Zoom headsets, or are you leaving it disabled (and/or blocking USB storage) and relying solely on HDX/Teams optimization for audio?

Really depends on the headset + software + ask. If the headset + any buttons they need work with virtual channels (also have to factor in endpoint/plugins), that's always the best route. But if there is advanced functionality either in headset software (conference room mics with speaker detection for example) or other UC app outside of Teams/Zoom, then you have to fall back to USB redirection.

You can do split redirects for buttons vs audio too

that's assuming the device exposes separate USB interfaces for the audio and the HID/button controls rather than presenting as a single monolithic USB device right?

Yes…