To whom it may concern, I am Simone Romagnoli, I am attempting to run the nf-core/chipseq pipeline (v2.0.0 and v2.1.0). I have correctly prepared the sample sheet and configured my environment to avoid using the default /tmp directory, as it does not have sufficient space. To redirect temporary files, I’ve added the following lines to my .bashrc: export TMP=/scratch/tmp_sromagnoli/ export SINGULARITY_TMPDIR=/scratch/tmp_sromagnoli export JAVA_OPTS="-Djava.io.tmpdir=/scratch/tmp_sromagnoli/" export NXF_OPTS="-Djava.io.tmpdir=/scratch/tmp_sromagnoli/" However, during pipeline execution—possibly during the phantompeak process—I still encounter a "No space left on device" error. The error message indicates that the pipeline is attempting to write to /tmp, for example /tmp/RtmpL1lT5P/, instead of the designated scratch directory. I have observed this issue with both v2.0.0 and v2.1.0 of the pipeline. Could you please advise on how to ensure that all temporary files, including those created by R processes, are correctly redirected to the specified scratch location? Thank you for your assistance. Best regards,