@Tim Riegler that’s broad question, what type of file server are you implementing (SMB, SOFS, Etc) and how many users are you looking to support - @Leee Jeffries wrote this throughout - In my experience Memory is the largest consideration. I have a client running SOFS with two nodes for FSLogix Profiles and Containers on the same disks. The CPU usage is low at 25%, 4 cores on each box. Memory is 14GB and that sits around 60-70% with 500 users spread across the two.