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As far as I know, and have tested, it's only possible to do exclusions at folder level.

Folder only I’m afraid

That's what I suspected - does anyone have any sage advise for policing/managing these? We currently have 30 users who have decided the profile is fair storage for anything and are sat at 15-20GB. More will follow I'm sure. We can delete the files but the VHDX file will still be at that size unless we delete the whole profile 😕 In the space of 2 months we're chewing up 8TB of flash storage 😞

You should take a look at this script from @Aaron Parker: https://github.com/aaronparker/FSLogix/tree/master/Profile-Cleanup ..and this FSLogix compacting tool by Citrix IRC: http://www.citrixirc.com/?p=1052 The cleanup script runs in user context, and removes files/folders defined in an XML file The shrink tool runs on the actual file server or the file share hosting the FSLogix containers

That compaction tool works well. We do a scheduled task to compact them during maintenance window.