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You should be able to use endpoint scans on the NetScaler.

Thanks Would this allow us to set a machine not able to connect unless it fulfills certain criteria.

Yes indeed. Exactly what it's for.

Thanks sir.

To do endpoint scan you will need NetScaler Gateway Endpoint Analysis MSI on Client Machine @Leee Jeffries Correct?

Spot on dude, you can grab this from the NetScaler or you can let users get the prompt , download and install.