Could we redirect Known Folders, like My Documents, Desktop and Downloads to Home Folder on Workspaces Pools https://docs.aws.amazon.com/workspaces/latest/adminguide/persistent-storage.html or is it not recommended? We want our users mainly to use Google Drive for Desktop for their file storage.

Known Folder redirection should be no problem. We encourage it as a best practice.

Thanks Kalon, is this best practice written in any blogs?

There aren't any blogs on the AWS side that talk about Known Folder Redirection. Mostly because it's more of a Microsoft Windows best practice irrespective of being in AWS. Doc link