I recently set up a new RDS farm that hosts RemoteApps, but users are prompted to enter their credentials after clicking on a RemoteApp. I've tried multiple solutions to enable SSO, but the only methods that have worked so far are launching the application through Internet Explorer or configuring the Enterprise Mode Site List for Microsoft Edge. Has anyone successfully enabled SSO without adding the RD Web Access URL to the Enterprise Mode Site List or launching the application via Internet Explorer?

We've had the same issue. When we first started moving from full RDS desktop sessions to RemoteApp and I had to setup Login VSI to test, the whole prompting for creds came up. I found out that users are 'used to' entering their creds twice (This is NOT Citrix! :)) This is really an issue with MSTSC.EXE which doesn't allow creds to be passed to it . This is by design, for security reasons. You are SUPPOSED to be able to modify the credential store and use that to SSO, but I have never been able to get that to work. One of my newer team members wrote a wrapper in C# that lets us automate this, but we're using our own broker and not RDWEB.

we'll probably try RDweb client