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@Benjamin Crill is the high IO coming from the Session Host or on the Storage Provider(s)? If you can outline your FSL config and infra design, that would help as there are many variables.

Citrix based VDI running on vSphere UCS hosts. Storage that VDI is on is Pure, FC connected array. Storage for FSLogix is a six node Nutanix Files cluster. The high IO we are seeing is on the VM the user is logging into and consequently the Pure array they are on. The Nutanix Files cluster sees very little compartively

FSL config?

2210 HF2. Cloud cache for profile and office container. Pointing to local file server first, then remote file server second. Separate shares for Profile and Office containers, but from teh same file cluster Comparison is same image in sub OU, that blanks out the CCDLocations and sets VHDlocations to local file server

When you say local vs remote file server are these SMB locations that are geo-disperse? If you'd rather discuss in a DM, I'd like to see your Registry or GPO settings for FSLogix. Do you have a redirection.xml? if so, what's in it? Generically speaking, CCD will have high IO for the local OS disk, always. This is because when a user signs in, we initialize a local VHD (proxy file, technically not stored on disk) and then read data from remote storage and pull it into the proxy file. All new IO writes to the users profile will occur to the local cache via the proxy file and THEN async streamed up to BOTH storage endpoints. Having both Profiles and ODFC will slightly increase the IO as we now are writing IO to 2 different local caches instead of a single local cache for just Profiles. Then if you combine that with user density on the same VM, your high IO can escalate quickly.

I'll DM you