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I have done this before with a combination of nFactor and EPA. You will have to do the domain check using epa then assign a pass or fail group based on the outcome of that. Then apply the session policy to the group (epa pass - ses_pol_epa_passed) etc then you can use smart access filters in Citrix policy to either enable or disable clipboard redirection based off that.

I was able to get this working. Do you know if we can disable “Skip check” during EPA scan or DENY access if Skip Check is pressed?

Yeah if you skip check then epa will me marked as failed. Need to apply a failed policy online to deal with that.