Some examples from my life that you might find parallels to:
At a consulting gig long back (angularjs days), I had to make something similar to datatables for showing products and orders, every single thing was editable and angularjs of that time did not like that many watchers at all.
The same project also had a CSV importer, this was back when webworkers were not a thing. Client wanted the UI to respond instantly when a user changed the delimiter for example. So server was not an option here.
At Verloop, we had some struggle with showing tons of analytics data and websockets.
While I was consulting Appsmith, they were going through perf fixes for reactivity (but this case might be an outlier because they're closer to a framework than your typical project)
Depending on what they might be looking for, some adjacent problems include figuring out ways to make embedded widgets lighter, build times faster etc.
Then there's the whole architecture level work so that big teams can work together aspect of scaling (that might not be relevant in this case, but is definitely important and worth mentioning if you've had experience in that)