🧬 Fresh case study: nf-core/sarek 3.6.1 with

aligner: parabricks

+ chained Parabricks DeepVariant on AWS spot, single A10G. NA12878 30× WGS, FASTQ → VCF in ~2h 32m for ~$2.59 (median over n=3 reproductions, 1.8% wall-clock spread). Validated against GIAB NIST v4.2.1 with hap.py + RTG vcfeval: SNP F1 = 0.9966, INDEL F1 = 0.9934 — model-weights-identical to CPU DeepVariant, ~8× faster end-to-end. Built on Clusterra: managed Slurm-on-AWS, in your own account, spin-up in ~15 min, flat monthly pricing (no per-sample, no enterprise sales call). https://clusterra.cloud Full writeup: https://clusterra.cloud/blogs/sarek-parabricks-case-study.html Happy to talk shop in DMs.