I’m trying a tool (CharGer) which can characterise cancer germline variants according to the ACMG pathogenicity guidelines. Although it’s not being maintained, it seems to still be functional. CharGer was used to analyse all the TCGA pathogenic germline variants published in Cell

Hello Abhay, this tool looks interesting. Did you encounter any issues with installations? With conda, it doesn't find it at all (even through the bioconda channels) and with pip, it encounters an error having to do with pyvcf (which doesn't look like it's being maintained anymore)

Set up Bioconda channels:

conda config --add channels bioconda
conda config --add channels conda-forge
conda config --set channel_priority strict

See https://bioconda.github.io/#usage