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If you're working on your own branches, no problem at all. If you're collaborating on a branch, not great. More info: https://graphite.dev/docs/collaborate-on-a-stack

I'm thinking more about comments - there are times that we may ask a question of a non-engineer on a PR who doesn't need to pull the branch or access the code....

Comments made in Graphite are posted into the GitHub PR, so as long as they had GitHub access to the repo before they will be able to see the comments added through Graphite

That’s right! Graphite syncs bidirectionally with Github, so any comments (including emoji reacts) posted on Graphite will show up on Github and vice versa.