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I haven't seen that anywhere at all as an official prereq

This article maybe? But hasn't been an issue for a long time. https://support.citrix.com/article/CTX284942/gateway-cannot-connect-to-the-citrix-xenapp-server-protocol-driver-error

Why would you use MBF except in a very few specific use cases, which are almost never the reason MBF is enabled.

NetScalers in Azure is where we leave it enabled by default as it is recommended there. you can/we have done it without MBF there but juice not worth the squeeze. NetScalers On Prem yea, we lean to disable it in most of ours BUT that being said, I haven't heard of it being a thing with interfering with EDT specifically?

I cant control what customers do, only comment on mbf when its found. Agree it has a limited niche use and most dont need it. The comment was from a post on Carl's blog. Ill give a bit of test i guess