EOL for 2019 is jan 2024. So less than a year. We run 2019 - no issues. But already planning to move to 2022. Keep good notes on issues/fixes as I will sure ask for them 8-)
And If you going to do any performance testing for user density - launch Teams for those test users.
Our current 2019 issues:
Searhindexer sometimes prevents users sessions from logout. (Doesn’t happen often - we keep checking sessions running over session limit and killing searchndexer there.)
RAM cache filling (also not something which is happening often, not often enough to find the root cause)
Couple of Windows Update related issues - these were cough during UAT and weren’t released to Prod - (start menu not launching, one drive not signing in)
VDA 2203 CU2 - significant increase in ICA Latency + Teams sometimes not turning on optimisation- we are in a proceed to rolling back to 1912 CU6