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The feeling of solving something like this is absolutely euphoric. I too had PVS target lock up issues that only presented themselves after the organization was 100% converted to a completely new 1912 environment. Re-built the image, removed aggressive software, anti-virus exclusions, 3rd party review, memory dump after memory dump to the Citrix escalation engineer, you name it. All the while users began complaining to the CEO. Turned out disabling the IPv6 checkbox in the image server's NIC was the solution.