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it works fine with MTU discovery

I did have MTU discovery enabled in the VDA, and the required settings in the ICA file in StoreFront.

MTU discovery has quite a few pre reqs/dependencies such as VDA version/Workspace app version/ADC firmware version

This was all internal, so no ADC involvement initially, but we met the other dependencies. Granted, this was 1912 LTSR base, so I guess it's possible that the issues we saw have been resolved in a CU or CWA release.

I had quite a few users where EDT just wouldn't work for them they would get connection errors or the desktop would lock up and freeze. When i updated to latest VDA and enabled MTU discovery on the VDA and latest workspace app and updated to latest Netscaler firmware at the time it was then fine

Now that I think about it, MTU discovery had a client requirement, but for older clients you had to add a line to the Default.ica file in StoreFront. Which is probably what I did.

yeah you could add it via the default.ica this has got some good info https://docs.citrix.com/en-us/citrix-virtual-apps-desktops/technical-overview/hdx/adaptive-transport.html#:~:text=%2Dto%2Dend)-,EDT%20MTU%20Discovery,failure%20to%20establish%20a%20session.

I think it might be time to test this feature again when the next major LTSR is released.

Yeah they definitely made improvements in VDA versions/ADC firmware/Workspace app in regards to MTU discovery and packet fragmentation so its good idea to re visit it. When it was first introduced it was a disaster caused us so many issues