Did a few (ha) of those this year, the few things I think of right away that stands out is the change in certificatenames, can't have special characters(* in this case) like *.
company.com anymore, needs to be something else. The only issues I had with NativeOTP was issues registering new users (only!) on Nutanix, but that only popped up for my testuser, and they never enroll anyone.. so not sure if it's fixed or not. Overall, no, a pretty easy upgrade path.