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I don't have an ultra wide, but I use a 42" 4K monitor. It was imperative that I be able to split it into 4 virtual 1080Ps. I use Virtual Display Manager which works great. Even Workspace App recognizes it so when I span desktop viewer in all 4 quadrants and maximize, my vdi session has 4 monitors. It makes maximizing and minimizing SOOO much better than having to size to a specific section of a giant monitor. Can't speak to the hotkeys specifically - are you referring to windows key combos? If so, I don't have a windows key on my Model M keyboard.

Thanks Brian, you're right, I should not have narrowed my question to ultrawide, as any high res display has the same challenges. In terms of hotkeys, yes Windows key combos are the first to come to mind that get processed by my local machine if my session is in Windowed Mode. The most common are Win+Arrow keys to snap windows to the left/right. Win+R for Run prompt is another one I used to use often. I'll check out Virtual Display Manager. Is this it? https://www.ishadow.com/

That's it. The only issue I've had so far is usually around meeting offloading - depending on the app, the multiple monitor isn't respected. Other than that, it's been great.

Thanks again for this recommendation, it worked great!