You're asking the wrong question. Graphene is a Python implementation of the GraphQL spec. Graphcool 1.0 is a database abstraction to aid in architecting a GraphQL server. Currently, Graphcool 1.0 only has a Node binding package, but as it develops, I'm sure there will be other language binding packages. In short, today you cannot use Graphcool with Graphene, but I bet someone will develop a binding package soon.