A community effort to collect a curated set of analysis pipelines built using Nextflow.

nf-core

<https://blog.google/innovation-and-ai/models-and-research/google-deepmind/alphagenome-atlas/|https://blog.google/innovation-and-ai/models-and-research/google-deepmind/alphagenome-atlas/>

Too bad there’s no CLI tool :disappointed:

oh wait, there is, but it’s API based
<https://github.com/mskilab-org/alphagenome-cli|github.com/mskilab-org/alphagenome-cli>

This is the first step before making it a db

FYI:
```Hi @matthdsm,

Welcome to the forum!

Yes, we provide datasets that you can download for offline computation here (<https://alphagenome.google/downloads>). The AVI scores are availble under a permissive license, with other datasets available for non-commercial use.

ENSEMBL have already integrated the AVI scores into VEP, as well as UCSC into their genome browser, so hopefully these will allow easy annotation with any existing pipelines you may have.

Tom```
Seems like offline score are already available :sweat_smile:
xref <https://www.alphagenomecommunity.com/t/offline-availability-of-precomputed-scores/964/2|alphagenomecommunity.com/t/offline-availability-of-precomputed-scores/964/2>

(both them, and you to join the forum and ask the question)

<https://github.com/Ensembl/VEP_plugins/blob/release/116/AVI.pm|github.com/Ensembl/VEP_plugins/blob/…/AVI.pm>

Should be easy enough to integrate. Stage dataset and enable the plugin in VEP

Insert meme:
• Famous last words
• What could go wrong
• 20 min adventure

I have my own side-quests today, but I'd be happy to join in on the fun

yeah :sweat_smile: my function here is purely FYI :smile:
Might be a cool beginner hackathon project though?