To go in reverse order:
1. Funcscan does support 'pre annotated' steps to allow people to skip running prokka, prodigal etc but that's it. We don't do anything outside of passing those to the screening tools skipped
2. Based on the diagram, we support HMMer (but with the assumption it's specifically for BGCs and AMP screening), interproscan (I don't remember why, @Anan Ibrahim added this), mmseqs2 only for taxonomic classification
3. . So I guess #C084HP11VPF is a more generalised version of funcscan ? So we are focusing more on prokaryotic genes of a very specific set of gene types