🎉 TrimGalore v2.1.0 — Oxidized Edition Beta 1 is live I would appreciate some help/feedback! Full Rust rewrite, drop-in replacement for Perl v0.6.x. Same CLI, same outputs. Extras in v2.1.0:

--discard-untrimmed

, JSON trimming report for MultiQC native parsing (once MultiQC is updated), MultiQC-compatible. Install: • crates.io:

cargo install trim-galore --version 2.1.0-beta.1

(the

--version

flag is required — plain

cargo install trim-galore

still resolves to v2.0.0 until GA) • Docker (tag):

<http://ghcr.io/felixkrueger/trimgalore:v2.1.0-beta.1|ghcr.io/felixkrueger/trimgalore:v2.1.0-beta.1>

— or

:beta

for the moving “latest beta” • Docker (digest, deterministic):

<http://ghcr.io/felixkrueger/trimgalore@sha256:3e5dd519ea992ce88eb6f01e8d051a33f356e9ecd2d45e79a9c9bd0ac05c5b77|ghcr.io/felixkrueger/trimgalore@sha256:3e5dd519ea992ce88eb6f01e8d051a33f356e9ecd2d45e79a9c9bd0ac05c5b77>

• Multi-arch:

linux/amd64

+

linux/arm64

nf-core/rnaseq integration: PR https://github.com/nf-core/rnaseq/pull/1789 is green on full matrix — x86 (40/40), arm64 (28/28), GPU (4/4). Pinned to image digest so runs are deterministic. No MD5 drift on reference outputs; MultiQC parses both report formats. Release notes: https://github.com/FelixKrueger/TrimGalore/releases/tag/v2.1.0-beta.1 GA-tracking PR: https://github.com/FelixKrueger/TrimGalore/pull/214 (draft,

do-not-merge-until-GA

) Announcement + feedback hub: https://github.com/FelixKrueger/TrimGalore/discussions/215 I am aiming for a 2-week beta window (planned release ~2026-05-03), assuming no critical issues. I would be very happy for some stress-testing, and to hear any feedback. Many thanks! 🫶