Hi, I arrive here from the Hackathon website. I have developed a similar pipeline (different choices of tools and a bit less heavy on the QC. I believe it would be great to contribute some of the modules I have ready, especially if you are going to release in nf-core. Unfortunately I can't join the hackathon myself, but someone in my team might be interested. Attached is the pipeline I have running, with the key differences being in tool choices (DeepVariant/DeepSomatic vs Clair) and SV/CN calling (SAVANA vs ASCAT & others), including ecDNA calling (Coral) and also not depicted I have a module that generates a circos plot as HMF style (attached example, includes some rough methylation data). Perhaps we could integrate different SNV/SV alternative paths.