Have you already seen this announcement from GA4GH about refget Sequence Collections? Like every standard, it is a quite complicated document, but it could be an interesting addition to the pipeline to optionally query their API with the reference genome being processed and then create this unique hash? "_Seqcol also handles sequence attributes, such as their names, lengths, or topologies. Like Refget sequences, seqcol digests are defined by a hash algorithm, rather than an accession authority_" "_Seqcol also provides a standardized method of comparing the contents of two sequence collections_"

Yeah agreed - I flagged it here but there wasn't a lot of discussion then.