Hello, would you be so kind to clarify how important the preseq option is? There's an option

--skip_preseq

so what are the cases when we should use it? Thank you.

Hi! preseq will be useful when you want to estimate the complexity of the sequencing library, see docs here (go to the preseq plot) but normally we advice not to run it by default and actually the

--skip-preseq

option is the default in #CE8SSJV3N and #CE5EL6326 and will be also in next #CFP55NZ5G release