Hi All, I have put some effort into solving this problem with a simple linear model in the base.config file to dynamically set resources. However, to make this a feature that is inclusive to all species and experimental metrics I agree with a similar approach to @Edmund and @Mahesh Binzer-Panchal. There has been a similar approach to this problem within the Galaxy community (https://arxiv.org/abs/2312.02060) but lacks the adaptability for scaling concerning input sizes. I would be happy to assist with the development of a plugin/database for this problem. Please reach out and let me know where I can be of assistance.