If you’re using LiveKit Cloud, the server both of these users would connect to would be (most likely) in India or Southeast Asia. If you’re using LiveKit Open Source, you’d want to run a server in India to service that region.
In either case, LiveKit doesn’t offer a peer-to-peer mode, so if your only server is in the US, both of these users will send their media to the US, where it will then travel back to India. This is just my guess, but it would increase latency by at least ~150-200ms.