@Thomas Busath I'm not aware of any general guidelines, but FWIW we've seen some similar things.
Increasing the number of API workers didn't initially increase throughput of requests to our server at all. After digging a bit more, we discovered that we were GPU bound. So, throwing more requests at the model by increasing API workers didn't help, but improving the model speed (e.g. via quantization, higher quality GPU, etc.) did. And once we did that, the API workers then became the limiting factor and we were able to see gains in throughput as we scaled up the # of API workers.